This is a PDMS-based device designed to allow peristaltic pumps to circulate both culture medium and glucose solutions to perform various tests such as intracellular Ca2+ measurements upon glucose challenge and dynamic insulin secretion based on glucose responsiveness.94 Since the autoimmune aspect of T1D is mediated by T-cells, the autoimmune status of this disease relies on the presence of islet autoantibodies. Here, INS is linked to type 1 diabetes mellitus.