In a model created by Li et al. upon activation of LSECs by molecular driver's characteristic of disease progression of NAFLD conditions (LPS, EGF, TNF-β) a significant increase in polymorphonuclear neutrophils (PMNs) bound to activated LSECs can be seen.112 These PMNs migrate to the hepatic chamber from the vascular channel in response to the pro-inflammatory molecular drivers after binding to the activated LSECs. The gene discussed is EGF; the disease is metabolic dysfunction-associated steatotic liver disease.