This is partially due to their ability to activate KCs and HSCs to promote fibrogenesis as well as promote the synthesis of endogenous cholesterol in a disease state of NAFLD.108 However, in a healthy liver, these cells display anti-inflammatory and anti-fibrogenic characteristics by preventing cell activation and regulating vasodilation.109 Additionally, LSECs have a high endocytic capacity, higher than any other cell in the body, due to their expression of endocytic receptors (e.g., macrophage mannose receptor, scavenger receptors, Fc gamma-receptor IIb2 (CD32B)). The gene discussed is TBCE; the disease is metabolic dysfunction-associated steatotic liver disease.