Considering TRPV4 is also involved in the transduction of itch sensation, this provides a hint that TRPV4 may play a significant part in the process of LPS infection‐associated itch in mice, prompting us to investigate the role of the implication of LPS‐TRPV4 interaction in itch signal transduction. The gene discussed is TRPV4; the disease is Pruritus.