Furthermore, TRIM26 has been demonstrated to inhibit the production of IFN-β and Interferon-stimulated Genes (ISGs) in an immortalized vaginal epithelial cell line (VK2) via the IRF3 pathway, thereby facilitating the infection of Herpes Simplex Virus type 2 (HSV-2) and enhancing its replication within the host [29]. The gene discussed is TRIM26; the disease is infection.