ALCAM macrophages were related to T cell proliferation[43] and T cell‐mediated responses through ALCAM‐CD6 interaction[44] We further annotated the cell subtypes of DC/macrophages and divided them into three subtypes in CRC tissue: ALCAMhigh macrophages, ALCAMlow macrophages, and DC/monocytes (Figure 2g). Here, CD6 is linked to colorectal carcinoma.