By tumor characteristics, ORR was 71.4% (95% CI, 29%-96%) for primary mucosal melanoma versus 24.1% (95% CI, 14%-38%) for primary cutaneous melanoma, and ORR was 31.5% (95% CI, 20%-46%) for BRAF wild-type melanoma versus 15.4% (95% CI, 2%-45%) for BRAF-mutant melanoma. This evidence concerns the gene BRAF and cutaneous melanoma.