In the TCGA cohort, relationships between the expression of 19 CRGs and clinicopathological features are shown in Additional file 2: Fig. S2A and B. Following multivariate Cox regression analysis and LASSO Cox regression, we identified NLRP3, ATP7B, SLC31A1, FDX1, and GCSH as potentially critical genes for constructing the prognostic signature in gliomas (Fig. 1A and B). Here, FDX1 is linked to central nervous system cancer.