Besides, the monoallelic c.2377C > T (p.Arg793*) variant in the SAMD11 gene found in IRD3 has been related to AR RP due to its interaction with the photoreceptor-specific transcription factor Cone-Rod homeobox (CRX) [65] and the Polycomb repressive complex 1 component (PRC1) [71], both implicated in the photoreceptor differentiation. Here, SAMD11 is linked to retinitis pigmentosa 1.