The traditional Japanese diet consists of a high intake of fish, miso, soy sauce, and vegetables; contributes to the prevention of ASCVD; lowers the risk for hypercholesterolemia, CAD, and non-HDL-C and increases serum HDL-C levels by genetic deficiency of cholesterol ester transfer protein (CETP) [65, 66]. The gene discussed is CETP; the disease is atherosclerosis.