Ten genes (S100A9, SRSF5, HNRNPDL, MCEMP1, CD96, NCF4, CTSW, CLIC1, HNRNPUL1, S100A6) and four genes (S100A8, RUNX3, SMAD7, ARF4) had common DEGs in RA|SLE|CD and RA|SLE|T1D datasets. Here, SRSF5 is linked to systemic lupus erythematosus.