For instance, amplification of 3q26 was detected in paired tumor foci of 50% cases (P1363, 1435 and P1476), harboring oncogene PIK3CA, SOX2 and BCL6. Additionally, amplification of CCND1 was detected in paired tumor foci of P1120, P1423, and P1476. The gene discussed is SOX2; the disease is neoplasm.