CYP11A1 and polycystic ovary syndrome: Surprisingly, the G05 subgroup significantly upregulates the expression of the CYP11A1 gene coding the cholesterol side chain cleavage enzyme which catalyzes the first step in the process of androgen synthesis, that is, the conversion of cholesterol to the precursor of androgen, pregnenolone, and is the key rate-limiting enzyme in androgen biosynthesis, which is also associated with polycystic ovarian syndrome (PCOS) induced female infertility characterized by hyperandrogenemia [27, 28].