SP1 binding motifs were enriched in cCREs of both EIF4A1 and GABARAP, and the binding affinity of this TF was predicted to be disrupted by the minor allele of regulatory SNV rs55894190 (r2 = 0.773, D′ = 0.988 with PD risk allele of PD GWAS-SNV rs12600861) within the EIF4A1 and NLGN2 cCREs. Here, SP1 is linked to Parkinson disease.