TF and Parkinson disease: For the downregulated PD GWAS-DEGs, the largest TF-DEG/PD GWAS-DEG regulatory networks were identified in the Micro1 cluster, with 79 TF-DEGs predicted to regulate 18 PD GWAS-DEGs, and the OPC1 cluster, with 87 TFs predicted to regulate 17 PD GWAS-DEGs (Fig. 6B).