KLF16 and Parkinson disease: Furthermore, SP3 binding motifs are enriched within cCRE regions of both ATXN7L3 and MPP2, while KLF16 is enriched for binding in cCRE regions of MPP2. Both are also among the overall most enriched TFs within cCREs of PD GWAS-DEGs in Exc5, and KLF16 is itself also encoded by a PD GWAS-DEG (Fig. 6A).