Downregulated DEGs across cell subtypes were enriched in pathways relating to DNA damage response, cellular stress response (including regulation of apoptosis), chromatin organization, catabolic processes (protein and other types), RHO GTPase signaling, cytoskeletal dynamics, kinase signaling, protein complex assembly, cancer pathways, and retinoic acid signaling (Fig. 2Ei). Here, RHO is linked to cancer.