It is mainly involved in neurotransmitter release and the regulation of neuronal cell plasticity [14–16]. Other studies have found that SNAP-25 can be involved in the regulation of autophagy [17–19], insulin secretion [20, 21], cancer [22, 23], dendritic and axonal growth [24], and learning and memory [25–27], et al. SNAP-25 also plays an important role in anti-parasitic infection. This evidence concerns the gene SNAP25 and parasitic infectious disease.