ADAM10 and Alzheimer disease: Administration of all-trans retinoic acid (20 mg/g), which was shown to upregulate ADAM10 transcription via binding to the two retinoid X-receptor/retinoic acid receptor (RXR/RAR) in the promoter, significantly increased the alternations in Y maze as well as decreased the escape latencies in the Morris water maze in the AD mice injected with AAV9-miR140-miR-122-eGFP, comparing with the AD mice received vehicle treatment (Fig. 3E, F and F’).