APP and Alzheimer disease: Given that ADAM10, the major α-secretase in CNS, is the common downstream target of miR-140 and miR-122, the potential influence of dysregulated miR-140/miR-122 expression on APP metabolism and AD-related pathologies have been studied in mice with ectopic hippocampal miR-140 and miR-122 expression as well as in vitro.