Moreover, proteins such as Mitogen-Activated Protein Kinase Kinase 1 (MAP2K1), Phosphoinositide-3-Kinase Regulatory Subunit 1 (PIK3R1), and Non-Receptor Tyrosine Kinase (SRC), associated with the VEGF signaling pathway, were significantly upregulated in ARDS, illustrating a comprehensive network of molecular interactions contributing to the pathogenesis and progression of ARDS. Here, MAP4K1 is linked to acute respiratory distress syndrome.