A previous experimental study has shown that mefloquine at 20 μM selectively and completely abolished the cell proliferation of two human PCa cell lines DU145 and PC3, by hyperpolarization of mitochondrial membrane potential and increased production of ROS resulting in rapid cancer cell death through inhibition of Akt phosphorylation and activated JNK, ERK and AMPK signaling [60–62]. The gene discussed is MAPK8; the disease is cancer.