POMC and urolithiasis: Stress was identified to be a risk factor for urolithiasis and the plausible mechanisms involved production of hypertonic urine secondary to stress-induced secretion of vasopressin, elevated serum calcium levels secondary to stress-induced adrenocorticotropic hormone (ACTH), increased uric acid and inorganic phosphorus concentrations, reduced potassium and magnesium levels and so on [12, 29, 30].