The role of secreted QSOX1 in ECM is an emerging and impactful concept without receiving adequate attention it deserves in the field of liver fibrosis research, however, it should be emphasized that QSOX1 mRNA is most abundantly expressed in the liver among various human tissues, including the heart, brain, placenta, lung, skeletal muscle, kidney and pancreas [18]. Here, QSOX1 is linked to Hepatic fibrosis.