Given the findings that aneuploidy increases with bladder cancer progression and that the vast majority (up to 90%) of MIBC exhibit a high degree of aneuploidy [25, 26], and the observations showing that DNA ploidy provides predictive characteristics for the survival of patients with BC, it is appealing to investigate the role of GJB3 in BC [27]. The gene discussed is GJB3; the disease is urinary bladder cancer.