MTOR and laryngeal squamous cell carcinoma: For example, Gao et al. [15] reported that circPARD3 could suppress autophagy through the atypical protein kinase C isoform PRKC iota- a kinase (PRKA) C-terminal domain (Akt)-mammalian target of rapamycin (mTOR) pathway, promoting malignancy progression and chemotherapy resistance in laryngeal squamous cell carcinoma.