Thus, it leads to the interaction of the enhancer with the promoter of the LZTFL1 gene at the 3p21.31 locus, consequently, upregulation of LZTFL1 occurs and, the epithelial-mesenchymal transition (EMT) process is suppressed which suggests exacerbating the COVID-19 outcome11. This evidence concerns the gene LZTFL1 and COVID-19.