CD4 and cancer: After quality control and dimension reduction using UMAP method, same number of cells from each group were combined together and the total cells were separated into 16 groups based on the marker gene reported (Fig. S5a) including cancer cell cluster 1-6, endothelial, fibroblast, hepatocyte, CD4+T, NK cell, B cell, macrophage, neutrophil, DC cells as shown in Fig. 3a.