In hepatocyte-specific Bcl6 knockout mouse model, Chikada et al. showed that Bcl6 knockout attenuated choline-deficient, L-amino-acid-defined, high-fat diet (CDAHFD) induced NASH and suppressed NASH-derived tumor progression27, implying a role of Bcl6 in liver lipid metabolism and lipoprotein transport. The gene discussed is BCL6; the disease is metabolic dysfunction-associated steatohepatitis.