Gene Ontology enrichment analysis of the ECD-rhythmic population alone showed that it is enriched with many known ECD-associated pathways, at direct term or child term, such as Interleukin-6 Production, C-type Lectin Receptor (Adaptive Immune System), KRAS (Signaling by Receptor Tyrosine Kinase), TP53 (Signaling by FGFR) or GnRH (HIV 1 Infection)41,52,53, as expected (Fig. 6a, italic). The gene discussed is GNRH1; the disease is HIV-1 infection.