(1) Whether CD8+ T cell subsets expressing GZMK are associated with the control of TB transmission, and whether CD8+/CD4+ T cell subsets expressing GZMB and CD4+ T cell subsets expressing GZMA are associated with the disease status of TB infection. (2) Functional role of GZMS and potential role of SOX4 in anti‐TB immunization. This evidence concerns the gene CD8A and tuberculosis.