Increased expression of CD44, CXCR4 and CD74 on group 1 and 2 NK cells, on which numerous signals from fibroblasts, endothelial cells, tumor cells and macrophages converged (COLLAGEN, MIF, LAMININ), facilitated the augmented incoming signaling in NSCLC (Fig. 6b,c). This evidence concerns the gene CD74 and neoplasm.