CD56bright cellular states exhibited increased inhibitory signaling (MHC-I) and augmented susceptibility to TME-induced suppression (MIF, COLLAGEN, LAMININ) whereas CD56dim states, particularly the effector state, exhibited high GZMA signaling, which was confirmed in samples of CD56dim from patients with NSCLC. This evidence concerns the gene LAMB2 and non-small cell lung carcinoma.