CXCR4 and neoplasm: Increased expression of CD44, CXCR4 and CD74 on group 1 and 2 NK cells, on which numerous signals from fibroblasts, endothelial cells, tumor cells and macrophages converged (COLLAGEN, MIF, LAMININ), facilitated the augmented incoming signaling in NSCLC (Fig. 6b,c).