CD69 and neoplasm: Importantly, tissue-, as well as tumor-annotated, NK cells, did not express human ILC signature genes (IL7R), instead expressing both EOMES and TBX21. Literature-derived tissue-residency genes (for example, CD69, ITGAE, ITGA1, CXCR6, ZNF683 and IKZF3), originally extrapolated from tissue-resident T cell signatures58–61, were more highly expressed in tissue-derived NK cells, particularly in CD56bright NK cells62.