FTO and neoplasm: The results of RNA methylation sequencing showed that, after FTO knockdown in GC cells, the methylation state of lots of genes especially the genes related to tumor metastasis and metabolism were markedly altered, indicating that FTO may play an obvious regulatory role in the occurrence and development of GC via regulating the homeostasis of RNA methylation and demethylation of malignant progression- or metabolism-related genes (Supplementary Fig. 3a–c).