To further determine whether FTO contributes to GC development by specifically regulating SP1-AURKB-ATM axis, we first investigated the biological functions of GC cells after FTO-knockdown with or without SP1/AURKB overexpression (NC, sh-FTO, sh-FTO+oe SP1, sh-FTO+oe AURKB). The gene discussed is FTO; the disease is gastric cancer.