SOD1 is an oxidative stress-inducible gene that mediates redox reactions and regulates bortezomib resistance in MM24, and in vitro functional studies have shown that forced expression of SOD1 induces resistance to bortezomib, while knockdown of SOD1 increases the sensitivity of drug-resistant MM cell lines to bortezomib25. The gene discussed is SOD1; the disease is Miyoshi myopathy.