The tumor suppressor genes breast cancer 1 (BRCA1) and breast cancer 2 (BRCA2) maintain cellular genome integrity through various processes, including homologous recombination (HR)-mediated repair of DNA breaks (Groelly et al, 2023; Scully and Livingston, 2000; Venkitaraman, 2019; Xu et al, 1999). The gene discussed is BRCA1; the disease is cancer.