Specifically in β-cells, TG-induced stress resulted in increased expression of ARID5B (part of demethylase complex), MAP1LC3A (Mitophagy), and CLIC1 (chloride channel) expression and decreased G6PC2 and HADH, which have been associated with diabetes (Fig. 6e, Supplementary Data 13). Here, MBD2 is linked to diabetes mellitus.