Specifically in β-cells, TG-induced stress resulted in increased expression of ARID5B (part of demethylase complex), MAP1LC3A (Mitophagy), and CLIC1 (chloride channel) expression and decreased G6PC2 and HADH, which have been associated with diabetes (Fig. 6e, Supplementary Data 13). This evidence concerns the gene ARID5B and diabetes mellitus.