Previous studies have shown that Sema3C could bind to the neuropilins (Nrp1 or Nrp2), to mediate downstream signal transduction.19 Moreover, NRP1 was up-regulated in HCC and promoted the expansion of CSCs and tumor growth.20,21 To this end, we examined whether NRP1 mediated the stemness maintenance for Sema3C in HCC. The gene discussed is NRP2; the disease is hepatocellular carcinoma.