SEMA3C and hepatocellular carcinoma: Previous studies have shown that Sema3C could bind to the neuropilins (Nrp1 or Nrp2), to mediate downstream signal transduction.19 Moreover, NRP1 was up-regulated in HCC and promoted the expansion of CSCs and tumor growth.20,21 To this end, we examined whether NRP1 mediated the stemness maintenance for Sema3C in HCC.