Sema3C has two directly binding receptors, NRP1 and NRP2, whose binding affinities are similar.16 NRP1 is highly expressed in HCC, contributing to tumor growth, metastasis, vascular remodeling, recurrence, and increased liver CSC populations in HCC patients.20,21 We demonstrated that Sema3C drives stemness maintenance by binding to NRP1. This evidence concerns the gene NRP2 and neoplasm.