The dynamic interaction between cancer cells and the ECM is crucial for regulating tumor growth.48 Tumor cells can remodel the ECM by regulating MMP and LOX family proteins.25,26 We found that Sema3C increases MMP2/9, LOX, and LOXL2 expression, enhances collagen I contraction in vitro, and promotes collagen deposition in an orthotopic HCC mouse model. Here, SEMA3C is linked to hepatocellular carcinoma.