Sema3C functions as an axon attractant for migrating cortical axons and promotes axon growth in human dopaminergic neurons, guiding motor neurons to specific targets.14 A previous study suggested that upregulated Sema3C is significantly correlated with tumor size and poor prognosis in HCC.15 However, the underlying mechanism of Sema3C up-regulation in HCC and whether it is implicated in the remodeling of TME remain unclear. Here, SEMA3C is linked to hepatocellular carcinoma.