Du et al. used GEO and TCGA databases to establish prognostic prediction models and explore FRGs-based treatment strategies for CRC patients, and found that the PI3K–AKT signaling pathway, YAK-STAT signaling pathway, Ras signaling pathway and MAPK signaling pathway were closely related to the ferroptosis pathway [38]. Here, PIK3CD is linked to colorectal carcinoma.