SREBF1 and cancer: Inhibition of PI3K, AKT, or mTOR has been shown to sensitize cancer cells to ferroptosis by decreasing sterol regulatory element-binding protein 1 (SREBP1), a central transcription factor regulating lipid metabolism, subsequently inhibiting stearoyl-CoA desaturase-1 (SCD1)-mediated synthesis of monounsaturated fatty acids (MUFA), which induces ferroptosis [21].