KAT6A and acute myeloid leukemia: A remarkable finding was that most of the cluster-3 proteins whose acetylation was specifically modulated by CM-444 and CM-1758 treatment were proteins that participate in the enhancer–promoter chromatin regulatory complex, and some have been shown to have important roles in AML, such as proteins containing bromodomains29 and those in the cohesin complex30, mediator complex31 or MOZ/MORF complex32, among others (Fig. 5C).