Furthermore, to investigate the impact of ARNTL2 on distant metastasis of NPC, we established a lung metastasis model and observed that the metastatic nodules on the lung surfaces were significantly fewer in the shARNTL2 group than in the control group (Fig. 7D), and H&E staining also presented consistent result (Fig. 7E). Here, BMAL2 is linked to nasopharyngeal carcinoma.