BMAL2 and nasopharyngeal carcinoma: ARNTL2 is a basic helix-loop-helix (bHLH) transcription factor [16] and was correlated with transcriptional misregulation in cancer in KEGG pathway analysis based on the differential genes of the RNA-seq data (Fig. 3A), indicating a potential role of ARNTL2 in gene transcription in NPC progression.