The following factors were found to be significantly associated with mortality: the number of lymph node metastases (P = 0.000), pericapsular invasion (P = 0.028), distant metastasis (P = 0.000), skin involvement (P = 0.010), vascular embolus (P = 0.007), lymphatic embolus (P = 0.000), DFS time (P = 0.001), and estrogen receptor (ER) positivity (P = 0.001). This evidence concerns the gene ESR1 and metastatic malignant neoplasm in the lymph nodes.