There is not a perfect equivalence between orexin deficiency and narcolepsy with cataplexy: about 10% of patients with cataplexy show CSF orexin > 110 pg ml−1 (above the current definition of orexin deficiency, with radioimmunoassay according to the standard reference of the Stanford values), and cataplexy is absent in 10%–30% of narcolepsy with orexin deficiency (Baumann et al., 2014; Mignot et al., 2002). Here, HCRT is linked to Cataplexy.