Remarkably, although we observed upregulation of CCNE1 after treatment with palbociclib in HNSCC cells, the addition of INK128 together with palbociclib could revert this overexpression and downregulated CCNE1 (Fig. 3B; Supplementary Fig. S3B). The gene discussed is CCNE1; the disease is head and neck squamous cell carcinoma.