EIF2S1 and cancer: Pathway enrichment analysis (Fig. 2B) identified a systematic enrichment of proteins in pathways associated with translational activity (e.g., EIF2 signaling, eIF4/p70S6K, mTOR pathway), inflammation (acute phase response signaling, LXR/RXR activation), cancer cell motility/invasion (actin cytoskeleton signaling), and altered glucose metabolism (gluconeogenesis, glycolysis).