Fig 1E shows the expression clustering and correlation results of ESM1. The results showed that ESM1, a part of the 14 endothelial cell cluster, is mainly expressed in endothelial cells and is associated with angiogenesis. Fig 1F shows the expression of ESM1 cell line. The results showed that ESM1 affected endothelial cells and fibroblasts, we hypothesized that its function might be related to cervical cancer migration and EMT [21]. Here, ESM1 is linked to cervical cancer.