TNF and cytomegalovirus infection: Notably, we detected lower frequencies of IFN-γ+ and IFN-γ+TNF+IL-2+ (triple positive) CD8+ T cells in noncontrollers than in HCs and KTR CMV controllers (Figure 1H and Supplemental Figure 1B), indicating a link between a diminished functionality of CMV-specific CD8+ T cells and the clinical observation of noncontrolled CMV infection.