The subsequent response of BDastrocytes to another pro-inflammatory cytokine, interleukin-1b (IL-1b), revealed aunique transcriptional response to inflammation, with further increased secretion ofIL-6 that directly and negatively impacted the activity of co-cultured neurons.Another study (Vizlin-Hodzic et al., 2017)detected increased expression of inflammation-related genes in BD patient-derivedNPCs. This evidence concerns the gene IL1B and Behcet disease.