Cell subsets and top genes of each cell subset identified through Wilcoxon ranked sum analysis are included in Figure 2, A and B. We identified 2 cell subtypes (CD4+IFIT+ cells and IFITM3+ IFN-activated monocytes) associated with genes related to IFN-pathway activation in RA. The gene discussed is IFITM3; the disease is rheumatoid arthritis.