On the whole, THBS1 facilitates obesity-associated expansion of the diaphragm FAP pool, inducing a fibrogenic transcriptomic signature typified by TGF-β–dependent gene expression and enrichment of a THY1+ subpopulation previously linked to tissue-level remodeling. The gene discussed is TGFB1; the disease is obesity due to melanocortin 4 receptor deficiency.