CD274 and Alzheimer disease: Given that the SASP-related inflammatory markers are augmented in many age-related diseases, there are reports indicating that the expression of PD-L1 is upregulated in coronary artery disease (CAD), obstructive lung disease (COPD), and Alzheimer’s disease (AD) (Saresella et al. 2012; Weyand et al. 2018; Polverino et al. 2022).