The findings of a recent mediation analysis on the Masstricht study, investigating the mediatory role of SHBG on the association between intrahepatic lipid content (IHL) and T2D showed greater mediatory role of SHBG in women compared to men, with a PM of 17.2% and 50.9% of SHBG on the association of IHL and T2D for men and women, respectively [31]. The gene discussed is SHBG; the disease is type 2 diabetes mellitus.