SHBG and type 2 diabetes mellitus: The results of a large systematic review and meta-analysis of observational studies on endogenous sex hormones and risk of T2D showed an inverse association of SHBG and risk of T2D in both sexes, although the findings were stronger in women than in men [7]; the same inverse association of SHBG with T2D was found in another systematic review and meta-analysis performed exclusively on women [25].