A 1991 guideline asserted that “black patients tend to respond better to diuretics and calcium antagonists than to beta-blockers or angiotensin-converting enzyme inhibitors as monotherapy.”53 Whelton et al. recommended “[f]or black adults with hypertension (without HF or CKD), initial antihypertensive treatment should include a thiazide diuretic or CCB.”25 The two most recent hypertension guidelines included in this review recommended different pharmacologic medications based on race.39,46. This evidence concerns the gene ACE and hydrops fetalis.