In addition, the proportion of GnRHR, LH and FSH positivity were higher in pituitary tumor with SF-1 expression than that without the expression [GnRHR: 24 of 25 (96%) vs. 54 of 80 (68%); P < 0.01, LH: 17 of 25 (68%) vs. 14 of 80 (18%); P < 0.01, FSH: 12 of 25 (48%) vs. 13 of 80 (16%); P < 0.01, Fig. 3]. The gene discussed is GNRHR; the disease is pituitary tumor.