The exosomes in the pancreatic tumor microenvironment contain RNA molecules, including but not limited to miR-10a-5p [11], miR-21 [12], miR-22 [8], miR-106b [13], miR-125b [8], miR-331-3p [14], miR-421 [15], miR616-3p [16], miR-1246 [17], miR-1290 [17], miR-3173-5p (Acyl-CoA Synthetase long chain family member 4 (ACSL4)-targeting miRNAs) [18], miR-4456 [16], miR-5703 [19], ANXA6/LRP1/TSP1 [8, 20], Hyaluronic Acid (HA) [21], tRF-19-PNR8YPJZ [22], as well as long non-coding RNA UCA1 [23] (Table 1). Here, ACSL4 is linked to pancreatic neoplasm.