ACSS2 and breast cancer: This indicates that targeting ACSS2 may be an effective method for treating BC patients.This geneACACB (Acetyl-CoA carboxylase beta) is believed to regulate fatty acid oxidation through the inhibitory effect of malonyl-CoA on carnitine-palmitoyl-CoA transferase I, the crucial step in mitochondrial fatty acid uptake and oxidation [42].