This study did not collect information on the presence of signet-ring cells or evaluate a potential association between this disease subtype and prevalence of CLDN18.2 positivity in patient tumor samples; however, previous studies have suggested a high prevalence of CLDN18.2 positivity and CLDN18 expression in signet-ring cell carcinoma [35, 36]. This evidence concerns the gene CLDN18 and signet ring cell carcinoma.