In addition, the intrabody containing the CD147 single-chain variable fragment (scFv) could decrease the expression of extracellular matrix metalloproteinase inducer (EMMPRIN) on the cell surface, leading to reduced cell proliferation, invasion, and metastasis, as well as induced apoptosis in the colorectal adenocarcinoma cell line Caco-2 [30, 31]. This evidence concerns the gene BSG and colorectal adenocarcinoma.